The Future Is Here Today...Robots, Genetics, AI, Longevity, Singularity

Add Intel’s CTO and senior fellow Justin Rattner to the growing list of singularity proponents according to an article from computerworld. According to Rattner:

“…perhaps as early as 2012 we’ll see the lines between human and machine intelligence begin to blur. Nanoscale chips or machines will move through our bodies, fixing deteriorating organs or unclogging arteries.  Sensors will float around our internal systems monitoring our blood sugar levels and heart rates, and alerting doctors to potential health problems.”

Rattner will be presenting his talk entitled “Crossing the Chasm Between Humans and Machines” at the Intel Developer Forum Aug 21, 2008. Come back here to the hub in August to see our review!

Nature recently published an article written by Armand Marie Leroi that opens with this interesting question:

“Now that many people approve the elimination of certain genetically defective fetuses, is society closer to screening all fetuses for all known mutations?

The article offers interesting statistics on the current state of genetically defective fetuses in the USA and how often these fetuses are aborted. The statistics clearly show that termination of the pregnancy of a genetically defective fetus is a widespread and growing phenomenon.

Although the abortion of a genetically defective fetus is quite controversial in the USA, Leroi points out that in many other countries it is morally acceptable, with 80% or more of such fetuses aborted in France and Taiwan compared to roughly 30% in the USA.

The moral and religious facets of aborting a genetically defective fetus are intentionally avoided in this article. Leroi’s intention is neither to promote nor discredit the abortion of genetically defective fetuses, but simply to report on the science and statistical trends that are taking place.

A significant impediment to a universal, total prenatal screen for all known mutations is the invasive and expensive nature of the procedure. Should the procedure become less invasive and less costly I suspect abortions of genetically defective fetuses would skyrocket, quickly overpowering most of society’s moral issues with the matter.

Below are interesting quotes from the article:

“Every year, 4.1 million babies are born in the USA.  On the basis of the well-known risk of Down syndrome, about 6,150 of these babies would be expected to suffer from this genetic condition, which is caused by an extra copy of chromosome 21. In reality, only about 4,370 babies are born with Down syndrome; the  there have been aborted during pregnancy…Data from other regions are similar or even higher: 32% of Down syndrome fetuses were aborted in Western Australia (Bourke et al, 2005); 75% in South Australia (Cheffins et al, 2000); 80% in Taiwan (Jou et al, 2005); and 85% in Paris, France (Khoshnood et al, 2004). Despite this trend, the total number of babies born with Down syndrome is not declining in most industrialized nations because both the number of older mothers and the conception rate is increasing.”

“This high number of so-called medical abortions shows that many people … consider the elimination of a genetically defective fetus to be morally acceptable

“…there is no technical obstacle to constructing an oligo-based micoarray able to detect all known disease-causing mutations”

“In Taiwan, screens for thalassaemia mutations have caused the live-birth prevalence of this disease to drop from 5.6 to 1.21 per 100,000 births over eight years (Chern et al, 2006).”

Ultrasound scan to amniocentesis test. Amniocentesis is a diagnostic procedure performed by inserting a needle (seen on the left) through the abdominal wall into the uterus and withdrawing a small amount of fluid from the sac surrounding the fetus. The test can detect chromosomal disorders, such as Down syndrome, structural defects, such as spina bifida (open spine, where the vertebrae fail to close), anencephaly (a condition in which the brain is incomplete or missing), and many rare, inherited metabolic disorders. © Mediscan/Corbis

Related to the IEEE special report on prosthetic arms is a fascinating article on prosthetic limbs that can take their signals directly from the nerves or even the brain of the user. As reported earlier, DARPA has given $30.4 million to initiate two separate prosthetic arm projects. The first project focuses on creating a noninvasive prosthetic arm and is being spearheaded by Deka as reported here. This article focuses on the second project which is aimed at connecting the user’s true intentions to the prosthetic arm either from the brain or from nerves.

One of the major problems with current prosthetic limbs is that they signal in only one direction, yet true human limbs signal on a bidirectional basis. Not only does the brain send signals to the limb to tell it what to do, but the limb sends signals back to the brain about what it is sensing in the form of pressure, temperature, and so on. The brain uses this sensory information to send adaptive instructions to the limb, allowing for the subtle or rapid changes that define true human agility. From the article:

“Sensory feedback for prosthetics is in the embryonic stages. The best mechanism on the market today consists of a vibrating motor that buzzes against the skin more or less intensely to reflect, for instance, such force factors as grip strength. The DARPA project is gunning for much more than that: researchers want an arm that transmits sensation to the user—pressure, texture, even temperature…with 100 sensors that connect the body’s natural neural signals to the mechanical prosthetic arm to create a sensory feedback loop…”

“As it turns out, the degree of control is directly proportional to the invasiveness of the method.”

The researchers are working with different levels of invasive interaction with the user, but there are two major categories of interaction.

The first category is to connect the muscles or nerve fibers that transmit signals from the brain to the limb. Even when a limb is lost, nerve fibers from the brain still exist up to the point where the limb was cutoff and amazingly they still function years after the loss of the limb. By connecting these nerve fibers to the prosthetic arm the signals from the brain to curl a finger or to clench a fist can still be accessed by interpreting the signals being transmitted across these nerve fibers. From the article:

“In a an individual with both limbs, those nerves travel from the spinal cord down the shoulder over the clavicle and then into the armpit, where they connect to about 80,000 nerve fibers that allow the brain to communicate with the arm.”

The second category is to entirely skip the nerve fibers and link directly into the neurons in the brain. From the article:

“Finally, the most extreme solution is meant for people whose bodies no longer offer any means for interfacing to the artificial limb, for whom even nerve-rerouting surgery may not be an option”

“When electrodes penetrate directly into the motor cortex, embedded electronic circuits intercept the motor neurons firing their instructions and, with the help of complex algorithms, translate the related signals into a language that can control the mechanics of the arms.”

In this piece from the IEEE special report on prosthetics we learn about Deka’s amazing noninvasive prosthetic arm. As noted earlier, DARPA gave $30.4 million to fund two projects for the next generation of prosthetic arms, one noninvasive and the other invasive. Deka is pursuing the noninvasive project which does not require any surgical access to anything inside the body such as nerves, muscles, or neurons.

Deka’s next generation prosthetic arm, called the Luke Arm (named in homage to the prosthetic arm used by Luke Skywalker in Star Wars) has overcome many of the signficant problems with the outdated prosthetic arms that are currently available. About the state of current prosthetic arms:

“…after the initial shock of amputation wears off, usually within a year or two, patients stop wearing their prostheses. Even extreme levels of amputation don’t much curb this tendency. Wearing the burdensome prosthetic is simply not justified by the small amount of assistance it provides…”

This accompanying video summarizes the project and is well worth your time!

Dean Kamen’s Robotic “Luke” Arm

HP, Intel, and Yahoo announced today the creation of a global cloud computing infrastructure to be used by researchers across the world.

Cloud computing is a computing model in which computing resources such as storage space and processing power can be remotely managed by a third party and sold to anyone at a price proportional to the amount of computing resources desired.

Huh?  Lets say you temporarily need 500 terabytes of storage and 1000 high powered computers to perform a graphics simulation quickly. Instead of buying and configuring these resources yourself you can simply rent these resources from a remote service that is connected to the internet (also known as the cloud).

Cloud computing is all the rage right now in the computing industry. Today’s announcement follows a string of similar high profile initiatives from Google, Amazon, IBM, Sun Microsystems, and others. To learn more click here or here.

In terms of the singularity, cloud computing represents a new phase in the creation of the global human mind that we call the internet. The internet can be thought of as a global repository of information that serves as an extension of the personal repository of information stored within our own brains. As man and machine race together towards the singularity this global mind serves as the universal platform for storage and retrieval of nearly all of the information and knowledge of mankind.

by Keith Kleiner on July 29th, 2008

In Feb 2008 IEEE Spectrum released a fantastic special report on some of the latest work being done on prosthetic arms.

The special report covers a lot of ground, but mostly focuses on DARPA’s Revolutionizing Prosthetics program:

“The program was created in 2005 to fund the development of two arms. The first initiative, the four-year, US $30.4 million Revolutionizing Prosthetics contract, to be completed in 2009, led by Johns Hopkins Applied Physics Laboratory in Laurel, Md., seeks a fully functioning, neurally controlled prosthetic arm using technology that is still experimental. The latter, awarded to Deka Research and Development Corp., Kamen’s New Hampshire–based medical products company (perhaps best known for the Segway), is a two-year $18.1 million 2007 effort to give amputees an advanced prosthesis that could be available immediately “for people who want to literally strap it on and go.” Kamen’s team designed the Deka arm to be controlled with noninvasive measures, using an interface a bit like a joystick.”

Because there are only about 6,000 prosthetic arms needed per year, the market has not been big enough to justify the large investment required to make next generation prosthetic arms. As a result it is amazing to note that commercially available prosthetic arm technology has not changed much in 100 years and is stuck in the “stone age”! Meanwhile prosthetic legs have seen significant investment and are extremely advanced and capable today.

The DARPA funding has literally changed the game by providing the investment necessary to propel prosthetic arms into the current era and beyond. In subsequent posts I will highlight some of the more notable aspects of this report.

by Keith Kleiner on July 29th, 2008

Michael Chorost published an article in MIT Technology Review about a networked pill from a company called Proteus Biomedical. The pill, called Raisin, releases a sand grain sized microchip into the body in addition to releasing the prescription.

This microchip is activated on contact with water in the body and sends electrical currents through the body as its form of communication. That’s right…no wireless signal, just electrical currents that are picked up by a receiver that is patched onto the body or as a subcutaneous insert.

There are two major advantages that this networked pill will offer. First, it will allow doctors to monitor whether patients are actually taking the medication in the quantity and frequency that they are supposed to by checking the logs from the receiver. Second, doctors can monitor physiological parameters such as heart rate before, during, and after taking the medication to better understand the impact of the medication on the patient. Some quotes from the article:

“…the dosages of drugs used for heart failure are derived from large
clinical trials and may not meet a particular patient’s needs. “Imagine
a situation where drug ingestion is tracked, and heart pressure before,
immediately after, and later are known,” says Saxon. “That represents
real, individualized, tailored drug therapy.”

“So far, Proteus has raised $60 million from investors including the
Carlyle Group and Kaiser Permanente Ventures, and it has filed more
than 250 patents. Clinical trials with human users began earlier this
year, to test the functionality of the IEM and sensors. The company
hopes to have the system on the market in 2011.”

Below is an interesting video of Michael Chorost speaking at Google June 30, 2008. Michael spends about half of the video explaining the amazing cochlear implant that has enabled himself and more than 100,000 deaf people around the world to regain their hearing. In the other half of the video Michael explores the future of man and machine, which is the focus of his upcoming book “World Wide Mind: The Coming Integration of Humans and Machines”. A few interesting themes from the video:

1.  There are only 100,000 people with cochlear implants in the world, yet there are 500,000 deaf people in the United States alone. It really is a shame that the gift of hearing is technically available yet not being given to the millions of deaf people around the world for due to cost and other reasons.

2. Michael describes the internet as a worldwide mind that we are all able to access and update. He explains how he felt disconnected from this “mind” when his blackberry was not functioning for a short period of time. This idea is one of the centerpieces of his upcoming book and is a major theme for all of us to consider as we envision the future of mankind.

3. Michael shows video clips of the incredible advances that are being made in interfacing the human brain with prosthetic limbs. Michael asks us to consider the implications and capabilities that will be unleashed for mankind as our ability to interface directly with the neurons of the brain improves in the coming years. The ability to read minds and the ability to purposely enhance the human body is considered.

Authors@Google: Michael Chorost

The Short:
Newscientist reports that researchers at the University of Toronto have created a microgripper device capable of grabbing and releasing objects as small as a cell. Tiny tweezers or grippers have been created by several researchers over the years, but what makes this microgripper unique is its sense of touch. From the article:

“The robotic gripper can exert as little as 20 nanoNewtons of force and are the first to be able to feel the strength of their grip on objects so delicately, says Yu Sun of the University of Toronto in Canada, who led their development.”

“The grippers are the first to not only feel their grip strength, but
also when they touch a surface. This allows them to sense when they’ve
run into things, helping them get close to cells and other objects
without damaging collisions.”


The Long:

The original research article can be found here. A few other interesting quotes:

“This paper reports on a monolithic MEMS-based microgripper with integrated force feedback along two axes and presents the first demonstration of forcecontrolled micro-grasping at the nanonewton force level”

“The tweezers’ arms are about 3 millimetres long, with fine tips able
to grasp cells just 10 micrometres across. In trials using pig heart
cells, the pincer could pick up and move the cells without damaging
them. Holding them with only 100 nanoNewtons of force, the gripper
squashed the cells out of shape by only 15%.”

“The grippers are controlled by software that can identify individual cells
and move the tweezers into position in just a few seconds. That’s much
faster than a person could do, Sun says.”

An amazing series of photos is presented below, showing how the microgripper was used to take three randomly placed cells and move them into a straight line:

Figure 11. Cell manipulation and alignment with force-controlled micrograsping. (a) After contact detection, the microgripper grasps a first cell. (b) The microgripper transfers the cell to a new position and releases the cell. (c) The microgripper grasps a second cell. (d) Transferring and releasing the second cell. (e) The microgripper approaches a third cell. (f) Transferring and releasing the third cell. Three cells of different sizes are transferred to desired positions and aligned.

Images are from the research article

The University of Texis at Austin reports that Professor Adela Ben-Yakar and colleagues have developed a femtosecond laser “microscalpel” that is so precise that it can destroy a single cell while leaving nearby cells intact.  According to the article:

“Within a few years, Ben-Yakar expects to shrink the probe’s 15-millimeter diameter three-fold, so it would match endoscopes used today for laparoscopic surgery. The probe tip she has developed alsocould be made disposable — for use operating on people who have infectious diseases or destroying deadly viruses and other biomaterials.”

“Femtosecond lasers produce extremely brief, high-energy light pulses
that sear a targeted cell so quickly and accurately the lasers’ heat
has no time to escape and damage nearby healthy cells. As a result, the
medical community envisions the lasers’ use for more accurate
destruction of many types of unhealthy material. These include small
tumors of the vocal cords, cancer cells left behind after the removal
of solid tumors, individual cancer cells scattered throughout brain or
other tissue and plaque in arteries.”

“A commercially available femtosecond laser system and microscope was
developed recently for LASIK and other eye surgeries, but the system’s
bulk limits its usefulness. Ben-Yakar’s laboratory has overcome
technological challenges to create a microscope system that can deliver
femtosecond laser pulses up to 250 microns deep inside tissue. The
system includes a tiny, flexible probe that focuses light pulses to a
spot size smaller than human cells.”

Adela Ben-Yakar has had success using similar laser devices to cut the connections (the axons) between individual nerve cells in a hunt for genes that control nerve regrowth after injury.

by Keith Kleiner on July 27th, 2008

I recently stumbled upon some articles on the oldest people alive and thought it would be interesting to post this information here at singularity hub:

The oldest person alive today (that can be verified against reasonable doubt) is Edna Parker, who turned 115 years old in April 2008. An interesting quote from the article:

“She has outlived both of her sons, and is one of 75 human beings in the world who have lived past the age of 110 years.”

Mariam Amash in Israel claims to be the oldest person alive at 120 years, but her age has not been confirmed reliably.

Wikipedia appears to have good information on the records for world’s oldest people. Jeanne Calment, who passed away in 1997, currently holds the record for longest documented lifespan at 122 years.

A supercentenarian is a person who has reached the age of 110 years or more, something achieved by only one in a thousand centenarians (based on European data). Furthermore, only 2% of supercentenarians live to be 115.

Picture from wickedlocal.com

The Short:
An IEEE Spectrum report and University of Michigan report tell of a fascinating advance in the development of a tiny microchip that can be implanted into the eye or other parts of the human body. The Phoenix microchip created my Michigan researchers would only require 1/30,000 as much power as comparable chips and would contain a sensor and a cpu enclosed in a 1 cubic millimeter package.

With such a low power microchip it would be feasible to run the chip for up to a year using current thin-film batteries. Countless applications for implants into the eye and other parts of the body would finally become feasible with a microchip that could operate on a battery for such an extended period.

The Long:

Some cool quotes from the University of Michigan article:

“The chip consumes just 30 picowatts during sleep mode. A picowatt is
one-trillionth of a watt. Theoretically, the energy stored in a watch
battery would be enough to run the Phoenix for 263 years.”

“Low power consumption allows us to reduce battery size and thereby
overall system size. Our system, including the battery, is projected to
be 1,000 times smaller than the smallest known sensing system today,”
Blaauw said. “It could allow for a host of new sensor applications.”

The microchip relies on a number of clever ideas to achieve its amazingly small power consumption. Chief among them is that unlike normal chips, this chip does not leak power when it is in idle mode (the period when it is not running instructions) which happens to be about 99% of the device’s lifetime. Essentially, the chip needs to turn on for a second or two and take a reading, then turn off for perhaps ten minutes before taking another reading. Another energy saving trick was to use a lower voltage, which causes the chip to run slower but in exchange causes it to use significantly less energy. From the IEEE article we see a number of other enhancements quoted here:

“Phoenix makes use of some other power-saving tricks.
It uses a very slow timer to tell the chip when to
switch back on and take a new sensor reading. Phoenix’s
timer operates at a frequency of less than one
oscillation per second, drawing just 2 pW. The
researchers also developed techniques for streamlining
the set of instructions the processor must be able to
execute and for compressing data in the chip’s memory.
With fewer instructions and less data to store, the chip
requires less memory, and because the volatile memory
embedded in microprocessors always requires power to
retain its contents, keeping the total amount of memory
down is important.”

Picture from ieee article