“Could someon say – purposely induce glucose spikes – during a sporting event? when needing to concentrate? ”

There is danger in this already. Too many Type 1 and Type 2 diabetics “float high” during work, so that they do not get a disastrous low blood sugar, impeding their performance. Over the long term this means more “glycosylation” of the body’s proteins, where those bind to glucose (a *very* reactive molecule), and bend out of shape, negating their function. There is a long list of secondary symptoms from this, and it is the major cause of lower average lifespan for diabetics.

“or perhaps actively force the glucose level very low?”

This is a short-term disaster, since low blood sugars starve the brain of the fuel it needs to survive. This is a major cause of death in Type 1 diabetics, because if they go low, their insulin bolus, already injected, just keeps diffusing insulin into the body’s tissues, lowering the available blood sugar further. At some point, unconsciousness happens, and with no treatment, death.

That is why artificial pancreas development that includes the hormone glycogen to cause the liver to drop glucose into the blood, as well as insulin, which gets the rest of the body’s cells to consume it from the blood, is an inherently safer system.

“Could someon say – purposely induce glucose spikes – during a sporting event? when needing to concentrate? ”

There is danger in this already. Too many Type 1 and Type 2 diabetics “float high” during work, so that they do not get a disastrous low blood sugar, impeding their performance. Over the long term this means more “glycosylation” of the body’s proteins, where those bind to glucose (a *very* reactive molecule), and bend out of shape, negating their function. There is a long list of secondary symptoms from this, and it is the major cause of lower average lifespan for diabetics.

“or perhaps actively force the glucose level very low?”

This is a short-term disaster, since low blood sugars starve the brain of the fuel it needs to survive. This is a major cause of death in Type 1 diabetics, because if they go low, their insulin bolus, already injected, just keeps diffusing insulin into the body’s tissues, lowering the available blood sugar further. At some point, unconsciousness happens, and with no treatment, death.

That is why artificial pancreas development that includes the hormone glycogen to cause the liver to drop glucose into the blood, as well as insulin, which gets the rest of the body’s cells to consume it from the blood, is an inherently safer system.