The Future Is Here Today...Robots, Genetics, AI, Longevity, Singularity

When you’re heart is broken, you’ll do anything to fix it. Even replace it with a pig heart. Scientists at the University of Minnesota have been working on stripping down hearts, removing much of the muscular and vascular tissue. What you get is a semi-translucent “decellularised” heart. Add some stem cells, and a new heart can be grown on this scaffold. A new heart that your body won’t reject, at least in theory. When Singularity Hub first brought you this story last year, researchers at UM were using the technique on rat hearts. Now, they’ve moved on to pig hearts and we’ve got a hold of some cool new pics and a short video from New Scientist. Check them out before and after the break.

At top, a rat's heart is decellularised until it becomes a scaffold. Stem cells from mice are then applied to the heart, and it is recellularised at bottom. Photo courtesy of University of Minnesota.

At top, a rat's heart is decellularised until it becomes a scaffold. Stem cells from mice are then applied to the heart, and it is recellularised at bottom. Photo courtesy of University of Minnesota.

It's alive! This rat heart is being pumped in an artificial structure, allowing stem cells to grow into a new version of the organ. Photo courtesy of the University of Minnesota

It's alive! This rat heart is being pumped in an artificial structure, allowing stem cells to grow into a new version of the organ. Photo courtesy of the University of Minnesota

The biggest problem is making sure that each heart grown is fully functioning and able to be transplanted. After being decellularised, each heart has to be recellularised by applying a coating of stem cells and having blood pumped through the heart scaffolding. Along with chemical signals from the scaffold cells, the blood allows the stem cells to specialize into the various needed tissues. Looking at the rat hearts in the pumping machine, it’s hard to believe that you are looking at a living, autonomous organ outside a body. Check out the video from New Scientist:

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The plastic 3-D printing machine has been around for a few years and man, is that cool. It can replicate most any mechanical system and it will function, too. Now, researchers at Organovo are taking things one step further, promising to be able to print entire organs for transplant patients. That technology would certainly be the jewel in the crown of the 3-D printing industry, but is Organovo living up to the hype? Will this company keep stride with the overactive imagination? Even if Organovo fails to deliver, there are still other promising methods for growing organs in the lab.

organ_printing

Printing blood vessels one plane at a time

Well, not quite. Although the website’s generic mission statement alludes to being able to print whole organs, like hearts or kidneys, that technology is quite a long way off. The research published by this federally funded project founded by Dr. Gabor Forgacs, a researcher at the University of Missouri, indicates that the company is first working on printing fully functioning blood vessels and arteries.

Organovo claims that printing blood vessels from the patient’s own cells will enable a transplant, like a bypass surgery, to work better. There is little to no chance of the patient rejecting the cells, as they are autologous. Another advantage of the bioprinting system is that there is no need for plastic scaffolding, which is said to cause inflammation and reduce the effectiveness of the transplant.

The idea behind the printing system is that the organ is printed layer by layer. A printer, using cell globules as ink, places them down onto a bio-degradable sheet of paper, where the cells naturally fuse together to create a small piece of the organ. A piece of bio-paper is put between each layer of the organ and, after all of the cells in the same layer are fused, the paper disintegrates and allows the different layers to fuse to each other. Eventually, after many layers, the blood vessel will materialize and be fully functional. Take a look at the video for a better explanation and some pretty 3-D computer model rendering:

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Growing new organs to replace old or damaged organs is no longer science fiction or something we will do in the future. It is happening now and real patients are having real organs that have been grown with their own tissue transplanted into their bodies. It is shocking that such an amazing revolution continues to remain virtually unnoticed by society!

Organs grown from a person’s own cells are the holy grail of medicine and human longevity. These organs are not rejected by the body’s immune system as foreign invaders because they actually originate from the patient. Here at singularity hub we will be following this field intensely as it may be one of the most revolutionary and game changing developments ever to beset mankind. Is your heart getting too old sir? No problem…lets just grow you a new one! The implications are stunning!

Below is a video from recent CBS coverage on regenerative medicine that is a must see if you are out of the loop on this amazing development:

Regeneration of cells – CBS Cutting Edge