Arun Vivian Holden

Arun Vivian Holden is emeritus professor of computational biology at the University of Leeds. The computational biology laboratory constructs detailed computer models of muscular organs—the beating heart, and the pregnant uterus—that are based on data from membrane, cell and tissue experiments, and from clinical data. These models are validated by their prediction of normal organ behavior, and abnormal behaviors seen in disease. They are applied to dissect, in space and time, physiological and pathological mechanism, to prescreen drugs, and to contribute to the drug design and discovery process, and the design of physical interventions.