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CRISPR


Latest significant advancements in CRISPR research. Reporting on the far-reaching impacts of CRISPR on society and humanity.

Designer Babies? Simulation Shows They Won’t Happen Anytime Soon

Roughly a year ago, the creation of CRISPRed twins reignited fierce debate and trepidation about our oncoming era of designer babies. The experiment, designed to protect the babies against HIV, failed miserably. But He...

Everything You Need to Know About Superstar CRISPR Prime Editing

All right, let’s do this one last time. My name is CRISPR. I was made from a bacterial defense system, and for years I’ve been the one and only gene editing wunderkind. I’m pretty...

CRISPR Just Created a Hornless Bull, and It’s a Step Forward for Gene-Edited Food

There’s a practice in farming not often talked about. To prevent accidental harm to human handlers and other cattle, bulls generally have their horn-producing cells surgically removed before the horns permanently attach to their...

With These 4 Breakthroughs, We’ll Be Able to Write Whole Genomes From Scratch

The ability to read genomes has transformed our understanding of biology. Being able to write them would give us unprecedented control over the fabric of life.  Rapid advances in DNA sequencing and gene editing technology...

Russia Could Take the Lead on Human Gene Editing

There's broad consensus that genetically modifying humans isn't a good idea, at least not anytime in the near future. But it seems Russia has less qualms about the idea, which could leave it to...

Cellular Computers Get a Boost With CRISPR

Cancer’s impenetrable secrets partly rely on its mysterious molecular history. As cells turn to the dark side, a whirlwind of DNA changes gradually accumulate. Like flipping multiple interlinked light switches, the cell gradually changes its...

California Passed the Country’s First Law to Prevent Genetic Biohacking

Genetic engineering technologies are quickly becoming mature and cheap enough for people to start using them in their own homes. That’s got scientists and officials worried, and California has now passed the first bill...

Inside China’s Play to Become the World’s CRISPR Superpower

In some ways, Hercules is pretty standard for the course where beagles are concerned. He likes to run around and generally looks as (borderline insanely) happy as any of his floppy-eared cousins across the...

Wait, What? The First Human-Monkey Hybrid Embryo Was Just Created in China

Last week, news broke that a prominent stem cell researcher is making human-monkey chimeras in a secretive lab in China. The story, first reported by the Spanish newspaper El País, has all the ingredients of...

First Human CRISPR Trial in the US Aims to Cure Inherited Blindness

Gene editing is advancing at a faster pace than most of us can keep up with. One significant recent announcement was gene editing tool CRISPR’s application to non-genetic diseases thanks to a new ability...

Editing RNA Expands CRISPR’s Use Far Beyond Genetic Diseases

CRISPR advances have been coming so frequently that it’s hard to keep track. In just a few years, it’s evolved from a nifty genome word editor to a full-on biological Swiss army knife. There’s the...

CRISPR in Russia: The World’s Next Gene-Edited Babies May Not Be Far Away

When Chinese scientist He Jiankui announced he had edited the genomes of two babies last November, he sparked an international outcry. Many feared he had opened the floodgates to human genetic engineering. It seems...

The Prickly Debate on Germline Gene Therapy, and Moving It Forward

In 2016, a healthy baby boy came screaming into the world in a Mexican clinic. Harboring DNA from three parents, the baby had had his genes dramatically altered while still an embryo. Without the...

The Hunt for a CRISPR Antidote Just Heated Up

When scientists behind the Manhattan Project heard of the destruction of Hiroshima and Nagasaki, their earlier exuberance gradually turned into morose regret. What began as a physics revolution had mutated into a weapon of...

CRISPR Used in Human Trials for the First Time in the US

CRISPR just hit another landmark. Last week, the University of Pennsylvania (UPenn) confirmed that they have treated two cancer patients using the gene editing darling married with another biomedical wizard, CAR-T. For now, it’s too...

A Deceptively Simple Tweak to CRISPR Makes It 50 Times More Accurate

CRISPR may be the premiere gene editing prodigy poised to upend natural genomes and erase inherited diseases. But since its inception, one thing has always stood in the way: accuracy. Back in 2017, a contentious...

New CRISPR Method Can Edit Over 13,000 Spots in a Single Cell

Dr. George Church, the legendary godfather of synthetic biology, just made another push towards massively editing life’s base code. Since the inception of gene editing, long before the CRISPR revolution, scientists have struggled with simultaneously...

The Three Frontrunners in the CRISPR Therapy Race

CRISPR is the ultimate child star in the biomedical universe. Just six years old, the gene editing prodigy is now the subject of multiple clinical trials that aim to push the lab tech into the...

The Gene Therapy Trial Aiming to Fend Off Alzheimer’s

There’s a test for Alzheimer’s risk that genetic counselors don’t like to talk about. It’s not that they’re hiding the information—rather, it’s because Alzheimer’s has no cure. There are no consensus methods to actively prevent...

Controversial ‘Gene Drives’ Just Worked in Mammals for the First Time

The phrase “gene drive” often sends a shudder down a scientist’s spine: one of awe, dread, and wonder. Tiny snippets of engineered DNA, gene drives are nuclear-grade powerhouses that utterly destroy the rules of inheritance....

CRISPR Just Got More Powerful With an “On” Switch

For all its gene-editing prowess, mechanistically CRISPR is a bit like a power tool with a broken “off” switch. Hear me out: the entire CRISPR machinery is designed in a test tube, and once constructed...

Gene Drives Survived a Proposed UN Ban in 2018—What’s Next?

In September 2018, a lab-based study published in Nature Biotechnology confirmed what many had long believed possible. The experiment involved cages of a few hundred mosquitoes, free to fly around and reproduce—but with a...

First Successful Pig-to-Baboon Heart Transplant Heralds Human Trials

An oddity of an animal lived and thrived in a lab at the Ludwig Maximilian University (LMU) of Munich in the past few years. On the surface, they looked like normal, healthy baboons. They hopped...

CRISPR Babies: Stumbling Over Mankind’s Next Giant Leap

During the last weekend in November, MIT Tech Review broke a world-changing story: the birth of the first children to have undergone gene editing as embryos. The Associated Press swiftly followed with a longer...

Welcome to the CRISPR Baby World—Here’s What You Should Know

Last week, the gene editing world was hit by news the equivalent of a nuclear bomb. In a video on YouTube, Dr. Jiankui He at Southern University of Science and Technology in China revealed that...

De-Extinction Is Now a Thing—Starting With Passenger Pigeons

When Martha the passenger pigeon died in 1914 at the Cincinnati Zoo, it marked the end of an era. Once the dominant species in eastern North America, passenger pigeons roamed the forests in giant flocks...

Healthy Mice Born From Same-Sex Parents For the First Time

When scientists made immature human egg cells from donated blood, some speculated that human reproduction was on the verge of a massive disruption. The future is now. Last week, a team from China completely overhauled natural...

New Study Is the Most Successful Attempt to Gene Edit Human Embryos So Far

In the quest for CRISPR supremacy, China just won another first. Last week, a team used CRISPR-Cas9 to correct a single mistaken DNA letter in over a dozen human embryos—and succeeded 16 out of...

Newly-Decoded Wheat Genome Opens the Door to Engineering Superfoods

Tweaking the DNA of crops to make them hardier and more productive is one of the most promising applications of gene-editing technology. That’s not been possible with wheat because its complex genome has proved...

New Study Sounds a Note of Caution in the Development of CRISPR Gene Therapies

The discovery of CRISPR gene editing technology led many to believe we may soon be able to tweak our DNA with ultra-high accuracy. But a new study has found it can cause more unintended...

New DNA Synthesis Method Could Soon Build a Genome in a Day

Synthetic biologists are the computer programmers of biology. Their code? DNA. The whole enterprise sounds fantastical: you insert new snippets of DNA code—in the form of a chain of A, T, C, G letters—into an...

Three Huge Ways Tech Is Overhauling Healthcare

We are on the brink of a revolution in healthcare. AI is making the drug discovery process >100X faster and cheaper, and 90 percent more likely to succeed in clinical trials. Mobile health is...

What Makes People Distrust Science? Surprisingly, Not Politics

Today, there is a crisis of trust in science. Many people—including politicians and, yes, even presidents—publicly express doubts about the validity of scientific findings. Meanwhile, scientific institutions and journals express their concerns about the...

The Epic Project to Record the DNA of All Life on Earth

Advances in biotechnology over the past decade have brought rapid progress in the fields of medicine, food, ecology, and neuroscience, among others. With this progress comes ambition for even more progress—realizing we’re capable of, say,...

Living Neanderthal ‘Mini-Brains’ May Reveal What Makes Our Brains Special

He isolated DNA from Egyptian mummies. He discovered the Denisovans, an extinct ancient human species, by sequencing DNA from a tiny bone fragment. He led a massive study that reconstructed the Neanderthal genome—and found...

Scientists Kick Off Synthetic Biology Project to Make Virus-Resistant Super Cells

Recently, roughly 200 eminent scientists assembled in Boston. Their agenda? Creating “superhero” human cells impervious to all viral attacks and possibly other killers—radiation, freezing, aging, or even cancer. The trick isn’t super-soldier serum. Instead, the...

This New Startup Will Use CRISPR as a Search Engine to Hunt Down Diseases

By now, you’ve heard of CRISPR—the bacterial self-defense mechanism that can be used to modify the genome. From “biohackers” building the hype by injecting themselves with CRISPR—and later regretting it—to the more measured, successful...

CRISPR-on-a-Chip For Diagnosing Cancer May Soon Be a Thing

Oh CRISPR, how you’ve grown. From an obscure part of the bacterial immune defense system, you’re now on track to cure genetic diseases, thwart superbugs, boost global food production, and wipe out disease-carrying pests. And...

Not Just Gene Editing—CRISPR Toolkit Expands With Trio of New Tricks

CRISPR, the superhero of gene editing, just got a little more super. In a trio of studies released last week in Science, leading CRISPR labs around the world unveiled some ultra-creative additions to the technique,...

New CRISPR Method Takes on Duchenne Muscular Dystrophy

The advance of CRISPR gene editing technology, which uses an RNA strand to guide an enzyme called Cas9 to cut a specific portion of DNA, has raised concerns and sparked debate as people envision...

Why Gene Silencing Could Launch a New Class of Blockbuster Drugs

Long before CRISPR, there was gene silencing. Ever since the Human Genome Project transcribed our genetic bible in 1997, scientists have dreamt of curing inherited diseases at the source. The first audacious idea? Shoot the...

Gene Therapy Had a Breakthrough 2017—2018 May Be Even Better

Gene therapy had a hell of a 2017. After decades of promises but failed deliveries, last year saw the field hitting a series of astonishing home runs. The concept of gene therapy is elegant: like...

New Research Suggests Immunity to CRISPR Gene Editing Poses a Challenge

CRISPR-Cas9 is the talk of the town in biotechnology. There is a huge amount of public interest in the possibilities provided by this new genome editing technology, and many are hoping CRISPR could eventually...
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How Neuroscience Is Beginning to Rewire the Brain From the Inside Out

In an interview at Exponential Medicine in San Diego, Singularity University faculty and speaker Dr. Divya Chander takes a look at how emerging technologies are letting us peer inside the human brain like never before. As an anesthesiologist...

The Enormous Promise and Peril of Bioengineering’s Pandora’s Box

We’re standing on the threshold of extraordinary capability in synthetic biology. CRISPR-Cas9, the genome editing technique discovered in 2014, is at the forefront of this newfound potential for innovation. These advancements provide an opportunity...

CRISPR Can Now Hitch a Ride on Nanoparticles to Battle Disease

It started like any other day. Dr. Hao Yin walked into the lab at MIT, ready to check on his transgenic mice. He had no idea he was about to make history. Yin’s mice harbored...
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You’ve Heard All About CRISPR Gene Editing—Here’s How It Works

Gene editing is in the news a lot these days, but what is it exactly? Gene editing is the process of making precise and permanent changes to living things at the level of DNA,...
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Do We Have the Right to Edit the Genes of an Entire Species?

Scientists can now more cheaply and efficiently edit animal and human DNA using the CRISPR/Cas9 gene editing system. But should we edit species, and if so, to what extent? An interesting way to consider this question...
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Tech-X-Planations | Introducing a New Original Weekly Video Series

We’ve all name-dropped a new technology that sounds awesome—like CRISPR/Cas9—without really knowing the basics. This is why we’ve created Tech-x-planations, Singularity Hub’s new weekly video series that explores fundamental ideas in science, technology, and the...

The Era of Human Gene Editing Is Here—What Happens Next Is Critical

Scientists in Portland, Ore., just succeeded in creating the first genetically modified human embryo in the United States, according to Technology Review. A team led by Shoukhrat Mitalipov of Oregon Health & Science University is reported to “have...

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