When you’re heart is broken, you’ll do anything to fix it. Even replace it with a pig heart. Scientists at the University of Minnesota have been working on stripping down hearts, removing much of the muscular and vascular tissue. What you get is a semi-translucent “decellularised” heart. Add some stem cells, and a new heart can be grown on this scaffold. A new heart that your body won’t reject, at least in theory. When Singularity Hub first brought you this story last year, researchers at UM were using the technique on rat hearts. Now, they’ve moved on to pig hearts and we’ve got a hold of some cool new pics and a short video from New Scientist. Check them out before and after the break.
 At top, a rat's heart is decellularised until it becomes a scaffold. Stem cells from mice are then applied to the heart, and it is recellularised at bottom. Photo courtesy of University of Minnesota. |
 It's alive! This rat heart is being pumped in an artificial structure, allowing stem cells to grow into a new version of the organ. Photo courtesy of the University of Minnesota |
The biggest problem is making sure that each heart grown is fully functioning and able to be transplanted. After being decellularised, each heart has to be recellularised by applying a coating of stem cells and having blood pumped through the heart scaffolding. Along with chemical signals from the scaffold cells, the blood allows the stem cells to specialize into the various needed tissues. Looking at the rat hearts in the pumping machine, it’s hard to believe that you are looking at a living, autonomous organ outside a body. Check out the video from New Scientist:
The ultimate goal, as you would guess, is to radically increase the availability of hearts for transplant in humans. While pig hearts provide a good scaffold, we may see human hearts (from cadavers) as the finalized product. Similar techniques are being used for livers, kidneys, and lungs. Using a patient’s stem cells, and either pig or cadaver scaffolding, doctors may be able to “grow” organs for transplant. Organs where most of the cells share the same DNA as the patient. It’s the ideal situation.
But we are years away from that case at the very least. The University of Minnesota first released information on their research on rat hears back in January 2008. Eighteen months later, and we’re just now seeing pig hearts in various stages of decellularisation. If and when recellularized pig hearts can be transplanted into pigs and keep them alive (the test already passed with rat hearts) we may hear talk about starting human trials. Judging by the slow but steady progress so far, this may be three to five years away. Fortunately, heart transplant patients have some experience with waiting and hoping.
From left to right: A normal pig heart, a pig heart after being decellularised, the pig heart prepared for recellularisation. Photos courtesy of the University of Minnesota.
Tags: decellularised, grow organs, hybrid hearts, organ harvesting, organ transplant, stem cells
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Wow that stuff looks straight Mad Science. I approve! Not that I’m not taking care of my heart, but you never know!
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