It’s been almost a year since we covered Dendreon announcing its successful Phase III clinical trials for its prostate treatment Provenge. Now, the Seattle based company is continuing its work of getting Provenge, also known as Sipuleucel-T, to the market. The revolutionary treatment for metastasized prostate cancer uses the body’s own immune system to hunt down and kill cancer cells that have spread beyond the organ. Upgrading the immune system’s T-cells with special proteins, a process called Active Cellular Immunotherapy (ACI), lets them hunt down cancer cells via the antigens embedded on their surface. ACI seems to work well for prostate cancer and Dendreon is expanding it to treat bladder, breast, ovarian and colon cancer with Lapuleucel-T (which has already completed Phase I trials). With all this good news it’s no wonder that Dendreon’s stock (NASDAQ: DNDN) continues to climb. While it’s still too soon to know if Sipuleucel will become the next popular weapon in the cancer fighting arsenal, all signs point to Dendreon enjoying continued success in the months and years ahead.
It's been a year of growth for Dendreon as their cancer fighting treatment continues towards FDA approval.
Prostate cancer affects more than a million men in the US alone, and kills thousands a year. While there exist successful treatment strategies if the cancer is caught early, once metastasized survival rates are low. Which is why Sipuleucel-T/Provenge is such a promising treatment. Recently, Dendreon released updated results from their Phase III trials, showing results better than previously seen. The median survival rate of patients with metastasized Castration-Resistant Prostate Cancer (CRPC) when taking Provenge was 4.1 months longer than similar patients on placebo. The 3 year survival rate was 32.1% for Provenge versus 23.0% for placebo (an improvement of about 40%). With 512 patients in these trials, they are a good sign that Dendreon’s treatment can markedly improve a man’s chances of survival.
Provenge may also help in other stages of the disease. Dendreon has half a dozen other clinical trials for Sipuleucel-T underway, looking to see if it could help in different stages of cancer treatment, and looking to optimize the ACI process.
That ACI process could be the goose that lays the golden eggs. While Sipuleucel is aimed at getting T-cells to recognize prostate cancer antigens, the technique could be adapted to other cancers. Hence we have Lapuleucel. What makes ACI so promising is that it is like an upgrade for your immune system. In the past, we’ve likened ACI to training your body’s cells into becoming nanobots ready to fight cancer. The analogy is fairly apt. During the Provenge treatment, your blood is drawn and the T-cells isolated. Then these cells are infused with proteins that code for cancer antigens. Finally the cells are reintroduced into your body. T-cells that were once unable to find and attack the cancer are now combat ready.
Part of what makes this approach appealing is that it is (mostly) autologous. That is, it uses your body’s own cells. There is something very engrossing about the idea of having your body provide its own cure for a disease. Autologous stem cell treatments may enjoy some increase in their popularity due to a similar perception. In the future, we may be drawn to treatment concepts that look to balance or harness the healing properties of our cells rather than treat them with external chemicals or even surgery. Perhaps that’s silly. But in a world of accelerating technology we must acknowledge that consumers exposed to treatments far outside their experience won’t only make health decisions based on effectiveness, but also on how ‘familiar’ or ‘comforting’ a treatment seems.
Which is probably a moot point for Dendreon. Not only is ACI a way to boost your own immune system with specially chosen proteins, it’s also proven to be effective for prostate cancer. With stock prices rising, one ground breaking treatment nearing FDA approval, and more in the pipeline, Dendreon seems to be an interesting bet for success (many tech investors are supportive of it). Though I’m certainly impressed with Sipuleucel-T/Provenge and excited by Lapuleucel, I think the real story here is ACI. It may take us years before nanoparticles can actively effect the growth of cancer. Immune system cells, however, are a form of quasi-nanotechnology that we can tap into in the near term.
Biological, chemical, or mechanical, I’m up for any technology that fights prostate cancer. Hopefully in the next year Dendreon will be even further towards its goal of improving the survival of those facing the disease.
[image credits: Google Finance, Dendreon]
[source: Dendreon, ClinicalTrials.Gov]
Comments
“Prostate cancer affects more than a million men in the US alone, and kills thousands a year. While there exist successful treatment strategies if the cancer is caught early..”
i am interested with prostate cancer recurrence after treatment..according to you what make this thing happened?
“Prostate cancer affects more than a million men in the US alone, and kills thousands a year. While there exist successful treatment strategies if the cancer is caught early..”
i am interested with prostate cancer recurrence after treatment..according to you what make this thing happened?
“Prostate cancer affects more than a million men in the US alone, and kills thousands a year. While there exist successful treatment strategies if the cancer is caught early..”
i am interested with prostate cancer recurrence after treatment..according to you what make this thing happened?
Not all of the other companies have failed. I’m also excited about GNBT, they had a positive PII for breast cancer. Their tech is a bit different though, http://www.antigenexpress.com
Not all of the other companies have failed. I’m also excited about GNBT, they had a positive PII for breast cancer. Their tech is a bit different though, http://www.antigenexpress.com
Not all of the other companies have failed. I’m also excited about GNBT, they had a positive PII for breast cancer. Their tech is a bit different though, http://www.antigenexpress.com
Hi Martin,
Actually, for end stage prostate cancer, the results are very impressive. This population typically only has 2+- years to live. They are at the end of their lives with no other treatment than chemo, which poisons them for what little time they have remaining.
Provenge gives them more than twice the time, with NO side effects so it does not destroy what remaining time the patient has left, it only makes it longer.
This is the FIRST company EVER to harness a patients immune system to fight an existing cancer. And there have been DOZENS of companies that have tried and failed. What will this technology do when given to people who are not on deaths door to help them fight their cancer? We will find out some day, and then you may find that you actually do have the cure.
That is what makes this treatment so revolutionary.
Hi Martin,
Actually, for end stage prostate cancer, the results are very impressive. This population typically only has 2+- years to live. They are at the end of their lives with no other treatment than chemo, which poisons them for what little time they have remaining.
Provenge gives them more than twice the time, with NO side effects so it does not destroy what remaining time the patient has left, it only makes it longer.
This is the FIRST company EVER to harness a patients immune system to fight an existing cancer. And there have been DOZENS of companies that have tried and failed. What will this technology do when given to people who are not on deaths door to help them fight their cancer? We will find out some day, and then you may find that you actually do have the cure.
That is what makes this treatment so revolutionary.
Hi Martin,
Actually, for end stage prostate cancer, the results are very impressive. This population typically only has 2+- years to live. They are at the end of their lives with no other treatment than chemo, which poisons them for what little time they have remaining.
Provenge gives them more than twice the time, with NO side effects so it does not destroy what remaining time the patient has left, it only makes it longer.
This is the FIRST company EVER to harness a patients immune system to fight an existing cancer. And there have been DOZENS of companies that have tried and failed. What will this technology do when given to people who are not on deaths door to help them fight their cancer? We will find out some day, and then you may find that you actually do have the cure.
That is what makes this treatment so revolutionary.
It seems like the survival rate is ill-defined. Looking at statistics for prostate cancer, the 5-year survival rate is close to 100 %, meaning that 5 years after diagnosis close to zero of the men have died of the disease.
http://www.cancer.org/docroot/CRI/content/CRI_2_4_1X_What_are_the_key_statistics_for_prostate_cancer_36.asp
It seems like the survival rate is ill-defined. Looking at statistics for prostate cancer, the 5-year survival rate is close to 100 %, meaning that 5 years after diagnosis close to zero of the men have died of the disease.
http://www.cancer.org/docroot/CRI/content/CRI_2_4_1X_What_are_the_key_statistics_for_prostate_cancer_36.asp
It seems like the survival rate is ill-defined. Looking at statistics for prostate cancer, the 5-year survival rate is close to 100 %, meaning that 5 years after diagnosis close to zero of the men have died of the disease.
http://www.cancer.org/docroot/CRI/content/CRI_2_4_1X_What_are_the_key_statistics_for_prostate_cancer_36.asp
Martin- simply because it prolongs S-U-R-V-I-V-A-L….and the way it does, by using the body’s immune system and not general poisons, is Revolutionary.
The survival rate was 4.2 months longer compared to Placebo treatment, and the 3 year survival rate was 32% compared to Placebo of 23%.
These numbers are not really impressive. How are the survival rates for other treatments (not placebo ) ?
Martin- simply because it prolongs S-U-R-V-I-V-A-L….and the way it does, by using the body’s immune system and not general poisons, is Revolutionary.
The survival rate was 4.2 months longer compared to Placebo treatment, and the 3 year survival rate was 32% compared to Placebo of 23%.
These numbers are not really impressive. How are the survival rates for other treatments (not placebo ) ?
The survival rate was 4.2 months longer compared to Placebo treatment, and the 3 year survival rate was 32% compared to Placebo of 23%.
These numbers are not really impressive. How are the survival rates for other treatments (not placebo ) ?
Martin- simply because it prolongs S-U-R-V-I-V-A-L….and the way it does, by using the body’s immune system and not general poisons, is Revolutionary.
Why is it a “revolutionary” treatment for prostate cancer, when it doesn’t cure the disease ?
Martin…4.2 months is the “median”…NOT the average increase in survival. It’s important to know the difference between the 2 terms.
The 32% 3 yr survival represents a 40% improvement. That’s significant.
It’s “revolutionary cuz there are insignificant side affects, where many victims would simply refuse treatment in the past due to the horrible aspects of chemo and lesser survivability.
Then there is the possibility of future boosters to increase survival even longer.
These facts are indeed “impressive”
Why is it a “revolutionary” treatment for prostate cancer, when it doesn’t cure the disease ?
Why is it a “revolutionary” treatment for prostate cancer, when it doesn’t cure the disease ?
Martin…4.2 months is the “median”…NOT the average increase in survival. It’s important to know the difference between the 2 terms.
The 32% 3 yr survival represents a 40% improvement. That’s significant.
It’s “revolutionary cuz there are insignificant side affects, where many victims would simply refuse treatment in the past due to the horrible aspects of chemo and lesser survivability.
Then there is the possibility of future boosters to increase survival even longer.
These facts are indeed “impressive”
Martin…4.2 months is the “median”…NOT the average increase in survival. It’s important to know the difference between the 2 terms.
The 32% 3 yr survival represents a 40% improvement. That’s significant.
It’s “revolutionary cuz there are insignificant side affects, where many victims would simply refuse treatment in the past due to the horrible aspects of chemo and lesser survivability.
Then there is the possibility of future boosters to increase survival even longer.
These facts are indeed “impressive”
just wondering if the author would like to disclose his investment position in DNDN?
just wondering if the author would like to disclose his investment position in DNDN?
just wondering if the author would like to disclose his investment position in DNDN?